Hugo Rodallega broke Burnley's hearts with a last-gasp winner to add to the Clarets' deepening relegation woes and keep Wigan on course for Barclays Premier League survival.
It is now 15 defeats from 16 top-flight matches on the road for Burnley, who came as close as they have done all season to finally ending their away-day hoodoo.
But deep into stoppage time Colombian striker Rodallega scored the most important goal of his nine for the Latics when he powered home a header from eight yards.
Hugo Rodallega of Wigan celebrates after scoring the winning goal during the Barclays Premier League match between Wigan Athletic and Burnley